In an era when India celebrates the call for an Atmanirbhar Bharat, we can’t ignore the archives of our industrial history to examine the life and times of a chemist who pioneered industrial self-reliance long before it became a state policy. Acharya Prafulla Chandra Ray, a professor-turned-entrepreneur, founded the Bengal Chemical and Pharmaceutical Works (BCPW) in 1892 with a paid-up capital of mere Rs 700. His efforts offer us a forgotten but profoundly relevant blueprint for today’s indigenous entrepreneurial surge. As India attempts to build its industrial strength amidst global supply-chain uncertainties, Ray’s experiment assumes a character that is more than a matter of historical nostalgia. It becomes a lens to examine what it truly takes to create a resilient, knowledge-driven, and socially conscious business ecosystem, whether from the periphery of an empire or, in today's case, from the constraints of global economic and industrial asymmetries. Ray’s story stands out among contemporary and leading enterprises for its fusion of science, swadeshi, and social justice into a coherent entrepreneurial vision.